Virological Monitoring of Wastewater as an Element of Surveillance for Emergent and Re-Emergent Infections
DOI:
https://doi.org/10.15407/Keywords:
virological monitoring, wastewater, poliovirus, enterovirus D68, SARS-CoV-2, monkeypox virusAbstract
The risk of biological threats has been constantly increasing in recent years. This is due both to the adaptation of avian and animal pathogens to the human organism as a result of the expansion of the area of human activity and to the development of biotechnologies. Viruses predominate among these pathogens. Examples in recent years are the COVID-19 pandemic and the continued spread of monkeypox (MPX). The situation requires the search for objects for research that would have a high informative value and could help in assessing and predicting the spread of infections. The article analyzed and assessed the potential and importance of virological monitoring of wastewater as an element of surveillance for emergent and re-emergent infections, using the example of some of them (enterovirus infections – poliomyelitis and infection caused by enterovirus D68, COVID-19, and MPX). Monitoring of enteroviruses in wastewater is a routine practice in many countries. Poliomyelitis is subject to eradication, and its incidence is extremely low. The study of wastewater makes it possible to indirectly detect the circulation of poliovirus among people, determine its molecular genetic characteristics (“wild”, vaccine, vaccine-derived poliovirus), the duration of circulation, and ways of spread and take appropriate measures in a timely manner. Enterovirus type D68 gained relevance as a re-emergent infection starting in 2014. Large outbreaks caused by it began to be registered in the USA, Canada, and then in the European region. Previously, the virus caused minor respiratory symptoms, but now it has become the cause of severe acute respiratory disease, particularly in children, and has also acquired neurovirulent properties. Its monitoring in wastewater allows for assessing the actual intensity of the epidemic process of this infection in certain territories and in certain countries, which cannot always be done based on clinical diagnosis without an additional etiological diagnosis. During the 3 years of the pandemic, SARS-CoV-2 has taken root in the human population, but a new parasitic system continues to develop. Wastewater monitoring makes it possible to assess the intensity of the epidemic process of COVID-19, which is supported by manifest forms of infection, asymptomatic persistence of the virus, and convalescents. It also allows for analyzing the effectiveness of quarantine and other restrictive measures, detecting genetic changes in the virus and trends in the formation of new variants of the virus. Since May 2022, MРХ has gone beyond the borders of endemic countries and began to spread rapidly, acquiring the character of a re-emergent infection. A variant of the pathogen (clade 3) began to evolve and became transmissible from person to person. The disease it causes began to radically differ from the previously known MRC due to changes in pathogenesis and epidemiological features. First of all, this concerns the pronounced anthroponotic characteristics of re-emergent MРХ in comparison with the zoonotic manifestations of the previously known endemic MРХ. The article discusses the results of studies conducted in different countries on the determination of MPX virus (MPXV) nucleic acids in wastewater samples using OPG002 gene analysis of all MPXVs (G2R_G), the West African clade (G2R_WA), and virus reference genomes of MPXV of the outbreak in 2022 (G2R_NML). Thus, virological monitoring of wastewater can be used as an effective element of surveillance for most infectious diseases, in particular, emergent and re-emergent ones.
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References
Aguiar-Oliveira, M. L., Campos, A. R., Matos, A., Rigotto, C., Sotero-Martins, A., Teixeira, P. F. P., & Siqueira, M. M. (2020). Wastewater-Based Epidemiology (WBE) and Viral Detection in Polluted Surface Water: A Valuable Tool for COVID-19 Surveillance-A Brief Review. Int J Environ Res Public Health, 17(24), 9251. https://doi.org/10.3390/ijerph17249251
Ahmed, W., Bertsch, P. M., Angel, N., Bibby, K., Bivins, A., Dierens, L., Edson, J., Ehret, J., et al. (2020). Detection of SARS-CoV-2 RNA in commercial passenger aircraft and cruise ship wastewater: a surveillance tool for assessing the presence of COVID-19 infected travellers. J Travel Med, 27(5), 116. https://doi.org/10.1093/jtm/taaa116
Battistone, A., Buttinelli, G., Fiore, S., et al. (2014). Sporadic isolation of sabin-like polioviruses and high-level detection of non-polio enteroviruses during sewage surveillance in seven Italian cities, after several years of inactivated poliovirus vaccination. Applied and Environmental Microbiology, 80(15), 4491-4501. https://doi.org/10.1128/AEM.00108-14
Brown, D. M., Hixon, A. M., Oldfield, L. M., Zhang, Y., Novotny, M., Wang, W., et al. (2018). Contemporary Circulating Enterovirus D68 Strains Have Acquired the Capacity for Viral Entry and Replication in Human Neuronal Cells. mBio. 9(5), e01954-18. https://doi.org/10.1128/mBio.01954-18
Chavarria-Miró, G., Anfruns-Estrada, E., Martínez-Velázquez, A., Vázquez-Portero, M., Guix, S., Paraira, M., et al. (2021). Time Evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Wastewater during the First Pandemic Wave of COVID-19 in the Metropolitan Area of Barcelona, Spain. Appl Environ Microbiol, 87(7), e02750-20. https://doi.org/10.1128/AEM.02750-20
Chen, W., & Bibby, K. (2022). Model-Based Theoretical Evaluation of the Feasibility of Using Wastewater-Based Epidemiology to Monitor Monkeypox. Environmental Science & Technology Letters, 9 (9), 772-778. https://doi.org/10.1021/acs.estlett.2c00496
Chin, A. W. H., Chu, J. I. S., Perera, M. R. A., Hui, K. P. Y., Yen, H. L, Chan, M. C. W., et al. (2020). Stability of SARS-CoV-2 in different environmental conditions. The Lancet Microbe. 1(1), е10. https://doi.org/10.1016/S2666-5247(20)30003-3
de Jonge, E. F., Peterse, C. M., Koelewijn, J. M.,, van der Drift, A-M. R., van der Beek, R. F. H. J., Nagelkerke, E., & Lodder, W.J. (2022). The detection of monkeypox virus DNA in wastewater samples in the Netherlands. Sci Total Environ. 15, 852, 158265. https://doi.org/10.1016/j.scitotenv.2022.158265
de Oliveira, L. C., Torres-Franco, A. F., Lopes, B. C., Santos, B. S. Á. D. S., Costa, E. A., Costa, M. S., et al. (2021). Viability of SARS-CoV-2 in river water and wastewater at different temperatures and solids content. Water Res. 1, 195, 117002. https://doi.org/10.1016/j.watres.2021.117002
Detection of circulating vaccine derived polio virus 2 (cVDPV2) in environmental samples- the United Kingdom of Great Britain and Northern Ireland and the United States of America. (2016). https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON408
Erster, O., Bar-Or, I., Levy, V., Shatzman-Steuerman, R., Sofer, D., Weiss, L., et al. (2022). Monitoring of Enterovirus D68 Outbreak in Israel by a Parallel Clinical and Wastewater Based Surveillance. Viruses. 14(5), 1010. https://doi.org/10.3390/v14051010
European Centre for Disease Prevention and Control: Update on the polio situation in the EU/EEA and the world. (2022). https://www.ecdc.europa.eu/en/news-events/update-polio-situation-eueea-and-world
Farkas, K., Williams, R., Alex-Sanders, N., Grimsley, J. M. S., Pântea, I., Wade, M. J., Woodhall, N., & Jones, D. L. (2023). Wastewater-based monitoring of SARS-CoV-2 at UK airports and its potential role in international public health surveillance. PLOS Glob Public Health. 3(1), e0001346. https://doi.org/10.1371/journal.pgph.0001346
Faye, M., Kébé, O., Diop, B., Ndiaye, N., Dosseh, A., Sam, A., et al. (2022). Importation and Circulation of Vaccine-Derived Poliovirus Serotype 2, Senegal, 2020-2021. Emerg Infect Dis. 28(10), 2027-2034. https://doi.org/10.3201/eid2810.220847
Ferraro, G. B., Veneri, C., Mancini, P., Iaconelli, M., Suffredini, E., Bonadonna, L., Lucentini, L., et al. (2022). A State-of-the-Art Scoping Review on SARS-CoV-2 in Sewage Focusing on the Potential of Wastewater Surveillance for the Monitoring of the COVID-19 Pandemic. Food Environ Virol. 14(4), 315-354. https://doi.org/10.1007/s12560-021-09498-6
Gigante, C. M., Korber, B., Seabolt, M. H., Wilkins, K., Davidson, W., Rao, A. K., et al. (2022). Multiple lineages of monkeypox virus detected in the United States, 2021-2022. Science, 378, 560-565. https://doi.org/10.1126/science.add4153
Girón-Guzmán, I., Díaz-Reolid, A., Truchado, P., Carcereny, A., García-Pedemonte, D., & Hernáez, B. (2023). Spanish wastewater reveals the current spread of Monkeypox virus. Water Res. 231, 119621. https://doi.org/10.1016/j.watres.2023.119621
Goverment of Canada: Polio (poliomyelitis): Wastewater surveillance. https://www.canada.ca/en/public-health/services/diseases/poliomyelitis-polio/wastewater-surveillance.html
GPEI Statement on cVDPV2 detections in Burundi and Democratic Republic of the Congo - GPEI (polioeradication.org). 2023, March,16.
Guardabassi, L., Dalsgaard, A., & Sobsey, M. (2003). Occurence and survival of viruses in composted human faeces. Sustainable Urban Renewal and Wastewater Treatment, 32, 58.
Guidelines for drinking-water quality: fourth edition incorporating the first and second addenda. Geneva: World Health Organization. 2022. Licence: CC BY-NC-SA 3.0 IGO).
Hill, D. T., & Larsen, D. A. (2022). Using geographic information systems to link population estimates to wastewater surveillance data in New York State, USA. medRxiv, 08.23:22279124. https://doi.org/10.1101/2022.08.23.22279124
Holshue, M. L., DeBolt, C., Lindquist, S., et al. (2020). First case of 2019 novel coronavirus in the United States. N Engl J Med. https://doi.org/10.1056/NEJMoa2001191
Howson-Wells, H. C., Tsoleridis, T., Zainuddin, I., Tarr, A.W., Irving, W. L., Ball, J. K., et al. (2022). Enterovirus D68 epidemic, UK, 2018, was caused by subclades B3 and D1, predominantly in children and adults, respectively, with both subclades exhibiting extensive genetic diversity. Microb Genom, 8(5), mgen000825. https://doi.org/10.1099/mgen.0.000825
Isidro, J., Borges, V., Pinto, M., et al. (2022). Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus. Nat Med, 28, 1569-1572. https://doi.org/10.1038/s41591-022-01907-y
Jones DL, Rhymes JM, Wade MJ, Kevill JL, Malham SK et al. (2023). Suitability of aircraft wastewater for pathogen detection and public health surveillance. Sci Total Environ, 856(Pt 2), 159162. https://doi.org/10.1016/j.scitotenv.2022.159162
Kilaru, P., Hill, D., Anderson, K., Collins, M. B., Green, H., Kmush, B. L., & Larsen, D. A. (2022).Wastewater Surveillance for Infectious Disease: A Systematic Review. American Journal of Epidemiology, 175. https://doi.org/10.1101/2021.07.26.21261155
Kline, A., Dean, K., Kossik, A. L., Harrison, J. C., Januch, J. D., Beck, N. K., et al. (2022). Persistence of poliovirus types 2 and 3 in waste-impacted water and sediment. PLoS One, 17(1), e0262761. https://doi.org/10.1371/journal.pone.0262761
Li, X. Y., Hou, J., Sun, Z., Han, W., Thilakavathy, K., Chen, W., et al. (2022). Monkeypox Virus 2022, Gene Heterogeneity and Protein Polymorphism. Research Square. https://doi.org/10.1038/s41392-023-01540-2
Lizasoain, A., Mir, D., Salvo, M., Bortagaray, V., Masachessi, G., Farías, A., et al. (2021). First evidence of enterovirus A71 and echovirus 30 in Uruguay and genetic relationship with strains circulating in the South American region. PLoS One, 16(8), e0255846. https://doi.org/10.1371/journal.pone.0255846
Lopalco, P. L. (2017). Wild and vaccine-derived poliovirus circulation, and implications for polio eradication. Epidemiol Infect, 145(3), 413-419. https://doi.org/10.1017/S0950268816002569
Masachessi, G., Castro, G., Cachi, A. M., Marinzalda, M. L. Á., Liendo, M., Pisano, M. B., et al. (2022). Wastewater based epidemiology as a silent sentinel of the trend of SARS-CoV-2 circulation in the community in central Argentina. Water Res, 219, 118541. https://doi.org/10.1016/j.watres.2022.118541
Matrajt, G., Naughton, B., Bandyopadhyay, A. S., & Meschke, J. S. (2018). A Review of the Most Commonly Used Methods for Sample Collection in Environmental Surveillance of Poliovirus. Clin Infect Dis off Publ Infect Dis Soc Am, 67, S90-S97. https://doi.org/10.1093/cid/ciy638
Meister, T. L., Brüggemann, Y., Todt, D., Tao, R., Müller, L., Steinmann, J., et al. (2023). Stability and inactivation of monkeypox virus on inanimate surfaces. The Journal of Infectious Diseases, 127. https://doi.org/10.1093/infdis/jiad127
Mejia, E. M., Hizon, N. A., Dueck, C. E., Lidder, R., Daigle, J., Wonitowy, Q., et al. (2022). Exploration of wastewater surveillance for Monkeypox virus. medRxiv, 2022.11.10.22282091. https://doi.org/10.1101/2022.11.10.22282091
Novel coronavirus may spread via digestive system: experts // Xinhuanet. - 2020-02-02. Electronic resource. Retrieved from: http://www.xinhuanet.com/english/2020-02/02/c_138749620.htm)
Otero, M. C. B., Murao, L. A. E., Limen, M. A. G., Caalim, D. R. A., Gaite, P. L. A., Bacus, M. G., et al. (2022). Multifaceted Assessment of Wastewater-Based Epidemiology for SARS-CoV-2 in Selected Urban Communities in Davao City, Philippines: A Pilot Study. Int J Environ Res Public Health, 19(14), 8789. https://doi.org/10.3390/ijerph19148789
Pennino, F., Nardone, A., Montuori, P., et al. (2018). Large-Scale Survey of Human Enteroviruses in Wastewater Treatment Plants of a Metropolitan Area of Southern Italy. Food Environ Virol, 10,187-192. https://doi.org/10.1007/s12560-017-9331-3
Quilliam, R. S., Weidmann, M., Moresco, V., Purshouse, H., O'Hara, Z., & Oliver, D. M. (2020). COVID-19: The environmental implications of shedding SARS-CoV-2 in human faeces. Environ Int, 140, 105790. https://doi.org/10.1016/j.envint.2020.105790
Rosenfeld, A. B., Warren, A. L., & Racaniello, V. R. (2019). Neurotropism of Enterovirus D68 Isolates Is Independent of Sialic Acid and Is Not a Recently Acquired Phenotype. mBio, 10(5), e02370-19. https://doi.org/10.1128/mBio.02370-19
Roshdy, W. H., El-Shesheny, R., Moatasim, Y., Kamel, M. N., Showky, S., Gomaa, M., et al. (2023). Whole-Genome Sequence of a Human Monkeypox Virus Strain Detected in Egypt. Microbiol Resour Announc, 8, e0000623. https://doi.org/10.1128/mra.00006-23
Rothman, J. A., Loveless, T. B., Kapcia, J., Adams, E. D., Steele, J. A., Zimmer-Faust, A. G., et al. (2021). RNA Viromics of Southern California Wastewater and Detection of SARS-CoV-2 Single-Nucleotide Variants. Appl Environ Microbiol, 87(23), e0144821. https://doi.org/10.1128/AEM.01448-21
Ryerson, A. B., Lang, D., Alazawi, M. A., et al. (2022). Wastewater Testing and Detection of Poliovirus Type 2 Genetically Linked to Virus Isolated from a Paralytic Polio Case -New York, March 9 - October 11, 2022. Morb Mortal Wkly Rep, 71,1418-1424. https://doi.org/10.15585/mmwr.mm7144e2
Sharkey, M. E., Babler, K. M., Abelson, S. M., Alsuliman, B., Amirali, A., Comerford, S., et al. (2022). First Detection of the Monkeypox Virus Using Wastewater-Based Surveillance in Miami-Dade County. https://doi.org/10.21203/rs.3.rs-2010415/v1
Sovic, M. G., Savona, F., Bohrerova , Z., & Faith, S. A. (2022). MixviR: an R Package for Exploring Variation Associated with Genomic Sequence Data from Environmental SARS-CoV-2 and Other Mixed Microbial Samples. Applied and Environmental Microbiology, 88(22), e0087422. https://doi.org/10.1128/aem.00874-22
Sridhar, A., Depla, J. A., Mulder, L. A., Karelehto, E., Brouwer, L., Kruiswijk, L., et al. (2022). Enterovirus D68 Infection in Human Primary Airway and Brain Organoids: No Additional Role for Heparan Sulfate Binding for Neurotropism. Microbiol Spectr, 10(5), e0169422. https://doi.org/10.1128/spectrum.01694-22
Steve, E. (2022). Hrudey and Bernadette Conant. The devil is in the details: emerging insights on the relevance of wastewater surveillance for SARS-CoV-2 to public health. Journal of water and health, 20(1), 246-270. https://doi.org/10.2166/wh.2021.186
Tedcastle, A., Wilton, T., Pegg, E., Klapsa, D., Bujaki, E., Mate, R., et al. (2022). Detection of Enterovirus D68 in Wastewater Samples from the UK between July and November 2021. Viruses, 14(1), 143. https://doi.org/10.3390/v14010143
Tisza, M., Javornik Cregeen, S., Avadhanula, V., Zhang, P., Ayvaz, T., Feliz, K., et al. (2023). Comprehensive Wastewater Sequencing Reveals Community and Variant Dynamics of the Collective Human Virome. medRxiv, 2023; 05.03:23289441. https://doi.org/10.1101/2023.05.03.23289441
Tiwari, A., Adhikari, S., Kaya, D., Islam, Md. A., Malla, B., Sherchan, S. P., et al. (2023). Monkeypox outbreak: Wastewater and environmental surveillance perspective. Science of The Total Environment, 856(2), 159166. https://doi.org/10.1016/j.scitotenv.2022.159166
Wannigama, D. L., Amarasiri, M., Hongsing, P., Hurst, C., Modchang, C., Chadsuthi, S., et al. (2022). Multiple traces of monkeypox detected in non-sewered wastewater with sparse sampling from a densely populated metropolitan area in Asia. Science of the Total Environment, 858(10), 159816. https://doi.org/10.1016/j.scitotenv.2022.159816
Weil, M., Mandelboim, M., Mendelson, E., Manor, Y., Shulman, L., Ram, D., et al. (2017). Human enterovirus D68 in clinical and sewage samples in Israel. J Clin Virol, 86, 52-55. https://doi.org/10.1016/j.jcv.2016.11.013
WHO: Statement of the Thirty-third Polio IHR Emergency Committee. 2022. 1 November. https://www.who.int/news/item/01-11-2022-statement-of-the-thirty-third-polio-ihr-emergency-committee
Wolfe, M. K., Duong, D., Hughes, B., Chan-Herur, V., White, J. B., & Boehm, A. B. (2022). Detection of monkeypox viral DNA in a routine wastewater monitoring program. MedRxiv. https://doi.org/10.1101/2022.07.25.22278043
World Health Organization. Department of Vaccines and Biologicals. Guidelines for environmental surveillance of poliovirus circulation (WHO/V&B/03.03). Switzerland. 2003. 19 р. - www.who.int/vaccines-documents/
Yamahata, Y., & Shibata, A. (2020). Preparation for Quarantine on the Cruise Ship Diamond Princess in Japan due to COVID-19. JMIR Public Health Surveill, 6(2), e18821. https://doi.org/10.2196/18821
Yinda, C. K., Morris, D. H., Fischer, R., Gallogly, Sh., Weishampel, Z., Port, J. R., et al. (2023). Stability of mpox (monkeypox) virus in bodily fluids and wastewater. bioRxiv. https://doi.org/10.1101/2023.05.09.540015
Zadorozhna, V., Demchyshyna, I., & Kotlik, L. (2019). The importance of national enterovirus surveillence in support for poliovirus surveillance in Ukraine. In: Сonference of the polio laboratory network, national poliovirus containment coordinators, national authorities for containment (Copenhagen, Denmark); 2019; Sept. 24-26, p.55.
Zadorozhna, V., Hrynevych, O., & Solomaha, L. (2015). Evolutionary changes epidemic process of enterovirus infections caused by enterovirus 68 D type: from sporadic cases for the coming epidemic. Profilaktychna medycyna, 24 (1-2), 3-15.
Zadorozhna, V. I., Sergeyeva, T. A., & Nekrasova, L. S. (2016). New influenza viruses and their associated risks (literature review and own research). Journal of the National Academy of Medical Sciences of Ukraine, 22(1), 45-55.
Zadorozhna, V. I., & Vynnyk, N. P. (2020). Koronavirus 2019-nCov: novi vyklyky dlya okhorony zdorov'ya ta lyudstva. Infektsiyni khvoroby, 1(99), 5-15. [In Ukrainian]. https://doi.org/10.11603/1681-2727.2020.1.11091
Zhao, C., Lin, X., Ji, F., et al. (2020). Prevalence and Bayesian Phylogenetics of Enteroviruses Derived From Environmental Surveillance Around Polio Vaccine Switch Period in Shandong Province, China. Food Environ Virol, 12, 321-332. https://doi.org/10.1007/s12560-020-09449-7
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